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ea0088006 | Abstracts | BES2022

NET proteome and bioenergetic profile of PMA- and ionomycin-stimulated neutrophils from people with established type 1 diabetes

Samal Bissenova , Darcy Ellis , Aisha Callebaut , Guy Eelen , Rita Derua , Mijke Buitinga , Chantal Mathieu , Conny Gysemans , Lut Overbergh

Background and aims: Type 1 diabetes (T1D) is a chronic autoimmune disease, characterized by T-cell mediated destruction of the pancreatic insulin-producing beta-cells. Neutrophils, cells of the innate immune system, have been shown to infiltrate the pancreas and undergo neutrophil extracellular trap (NET) formation (NETosis). However, little is known about the involvement of neutrophils and specifically the role of NETosis in the pathophysiology of the disease. Our aim was to...

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ea0088003 | Abstracts | BES2022

A plasma miR-193b-365 signature predicts non-responsiveness to Lactococcus lactis-based antigen- specific immunotherapy in new-onset type 1 diabetes

Gabriele Sassi , Giada Licata , Giuliana Ventriglia , Darcy Ellis , Damme Niels Van , Yvan Saeys , Silvia Caluwaerts , Alessia Mori , Pieter Rottiers , Chantal Mathieu , Francesco Dotta , Conny Gysemans , Guido Sebastiani

Background and aims: Combining systemic immunomodulation with disease-relevant antigens could provide longer-term solutions for preventing and even reversing autoimmune type 1 diabetes (T1D). Our team established that a combination therapy (CT), composed of a short-course low-dose anti-CD3 treatment with oral delivery of genetically-modified Lactococcus lactis (L. lactis) bacteria secreting full proinsulin plus the anti- inflammatory cytokine IL-10 (LL-PINS+I...

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Endocrine Abstracts

NET proteome and bioenergetic profile of PMA- and ionomycin-stimulated neutrophils from people with established type 1 diabetes

A plasma miR-193b-365 signature predicts non-responsiveness to Lactococcus lactis-based antigen- specific immunotherapy in new-onset type 1 diabetes

BiosciAbstracts